Recombinant North American type 1 porcine reproductive and respiratory syndrome virus and methods of use
US8182984B2 · kind B2 · utility
0Cited by
19References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 24, 2008 |
| Grant date | May 22, 2012 |
| Priority date | — |
| Expiry date | Dec 5, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/10061
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major problem in the pork industry worldwide. The inclusion of markers in vaccines will allow for diagnostic differentiation of vaccinated animals from those naturally infected with wild-type virus. Using a cDNA infectious clone of North American Type 1 PRRSV, a recombinant green fluorescent protein (GFP) tagged PRRSV has been made, containing deletion of an immunogenic epitope, ES4, in the nsp2 region. GFP and ES4 epitope-based ELISAs compliment the marker identification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.