Methods for in vitro differentiation of Th-17+cells
US8183040B2 · kind B2 · utility
2Cited by
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13Claims
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Key dates
| Filing date | Apr 15, 2009 |
| Grant date | May 22, 2012 |
| Priority date | — |
| Expiry date | May 26, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells).The instant method may be used to generate a population of human T helper lymphocytes that express IL17 (Th-IL17+ cells) in vitro. Methods for screening to identify agents capable of modulating Th-IL17+ cell differentiation are also encompassed by the present invention. Isolated, pure populations of homogeneous Th-IL17+ cells that do not express cellular markers characteristic of Th1, Th2, or Treg cells are also encompassed herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.