Bicyclic and tricyclic compounds as KAT II inhibitors

US8183238B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Michelle Marie Claffey · Stonington, US
• Amy Beth Dounay · Colorado Springs, US
• Matthew Merrill Hayward · Old Lyme, US
• Suobao Rong · Doylestown, US
• Patrick Robert Verhoest · Newton, US
• Jamison Bryce Tuttle · Pasadena, US
• Xinmin Gan · Ann Arbor, US

Key dates

• Filing date: Jun 16, 2010
• Grant date: May 22, 2012
• Expiry date: Jun 16, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula X:wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other neurodegenerative and/or neurological disorders in mammals, including humans.