Substituted pyrrolo[2,3-d]pyrimidines and compositions as protein kinase inhibitors

US8183248B2 · kind B2 · utility

Assignee

• IRM Inc. · BM

Inventors

• Advait Suresh Nagle · San Diego, US
• Nathanael S. Gray · Boston, US
• Yi Liu · San Diego, US
• Pingda Ren · San Diego, US
• Taebo Sim · San Diego, US
• Shuli You · Shanghai, CN

Key dates

• Filing date: May 10, 2006
• Grant date: May 22, 2012
• Expiry date: Dec 24, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Abl, Bcr-Abl, Bmx, BTK, b-RAF, c RAF, CSK, cSRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK1α1, JNK2α2, Lck, Met, MKK4, MKK6, p70S6K, PAK2, PDGFRα, PKA, PKCα, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, SGK, Syk, Tie2 and TrkB kinases.