Patent · US Active

Inhibitors of AKT/PKB with anti-tumor activity

US8183249B2 · kind B2 · utility

7Cited by
7References
16Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 14, 2008
Grant dateMay 22, 2012
Priority date—
Expiry dateAug 11, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07H19/23
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.