2-adamantyl-butyramide derivatives as selective 11β-HSD1 inhibitors
US8183265B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Nov 22, 2007 |
| Grant date | May 22, 2012 |
| Priority date | — |
| Expiry date | Mar 24, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/185
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.