Virus coat protein/receptor chimeras and methods of use
US8183354B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 2007 |
| Grant date | May 22, 2012 |
| Priority date | — |
| Expiry date | Jan 29, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occn-panty of co-receptor present on the cell, for example. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HIV, SIV, FIV, FeLV, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CCR5 and CXCR4 sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.