Puumala virus full-length M segment-based DNA vaccines
US8183358B2 · kind B2 · utility
5Cited by
1References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 12, 2008 |
| Grant date | May 22, 2012 |
| Priority date | — |
| Expiry date | Aug 29, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/175
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention contemplates a new synthetic, codon-optimized Puumala virus (PUUV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The PUUV ORF was cloned into a plasmid to form the first stable PUUV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a molecular vaccine system, and is useful to protect mammals against infection with Puumala virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.