Ligands, their preparation and uses thereof in asymmetric reactions

US8183378B2 · kind B2 · utility

Assignee

• Chao Li · CA

Inventors

• Chao Li · East Lyme, US
• Jianqing Feng · Suzhou, CN

Key dates

• Filing date: Nov 7, 2008
• Grant date: May 22, 2012
• Expiry date: Sep 9, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel chemical agents are described herein. More a ligand of general Formula I:wherein R1, R2, R3 and R4, are independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 alkoxy, C1-C10 alkylthio, C(O)R5, C(O)OR5, C(O)NHR5, Si(R5)3, benzyl and aryl; X is selected from the group consisting of Cl, Br, I, OR6, O-Prot, OPR6, P(R6)2, NHR6, N(R6)2, NHCSNHR6, NHCONHR6 and SR6; and R5 and R6 are independently selected from the group consisting of hydrogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-10 alkoxy, phenyl, and aryl. These ligands are useful in asymmetric reactions as well as in asymmetric synthesis of molecules of biological interest.