Antitumor agents

US8183379B2 · kind B2 · utility

Assignee

• Wayne State University · US

Inventors

• Jerome P. Horwitz · Farmington Hills, US
• Lisa Polin · Oak Park, US
• Stuart T. Hazeldine · Taylor, US
• Thomas H. Corbett · Grosse Pointe Park, US

Key dates

• Filing date: Nov 14, 2008
• Grant date: May 22, 2012
• Expiry date: Sep 3, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula I:wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof, and methods of inhibiting cancer cells.