Chimeric PCSK9 proteins, cells comprising same, and assays using same
US8187833B2 · kind B2 · utility
3Cited by
3References
16Claims
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Key dates
| Filing date | May 8, 2007 |
| Grant date | May 29, 2012 |
| Priority date | — |
| Expiry date | Nov 16, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.