Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein
US8187872B2 · kind B2 · utility
10Cited by
27References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 20, 2011 |
| Grant date | May 29, 2012 |
| Priority date | — |
| Expiry date | Oct 20, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.