Patent · US Active

Anti-microbial peptidomimetic compounds and methods to calculate anti-microbial activity

US8188033B2 · kind B2 · utility

1Cited by

1References

16Claims

0Family size

Inventors

Rickey P. Hicks · Greenville, US
Diva Karamenon Venugopal · Gaithersburg, US
Jayendra Bhonsle · Germantown, US

Key dates

Filing date	Dec 20, 2007
Grant date	May 29, 2012
Priority date	—
Expiry date	Feb 27, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention encompasses synthetic antimicrobial peptide analogs having certain un-natural amino acids, including the un-natural amino acids hydrophobic tetrahydroisoquinolinecarboxylic acid (Tic) and octahydroindolecarboxylic acid (Oic), incorporated into the polypeptide backbone. These antimicrobial peptides (AMPs) are useful to treat infection in humans and other mammals of such bacteria as Gram positive bacteria, Gram negative bacteria and Mycobacterium. Many of the AMPs also exhibit the property of reduced hemolytic activity. The invention also entails 3D-QSAR models and mathematical equations that calculate the biological activity of any peptide sequence against Staphylococcus aureus or Mycobacterium ranae.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.