Patent · US Active

Specific salt, anhydrous and crystalline form of a dihydropteridione derivative

US8188086B2 · kind B2 · utility

8Cited by

29References

5Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Guenter Linz · Mittelbiberach, DE
Peter Sieger · Mittelbiberach, DE
Matthias Grauert · Ingelheim am Rhein, DE
Rolf Schmid · Gelterkinden, CH

Key dates

Filing date	Sep 17, 2008
Grant date	May 29, 2012
Priority date	—
Expiry date	Sep 17, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallization in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.