Methods of monitoring cellular death using low frequency ultrasound
US8192362B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2006 |
| Grant date | Jun 5, 2012 |
| Priority date | — |
| Expiry date | Oct 1, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N5/10
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of detecting cellular damage within a subject comprises transmitting low frequency ultrasound (20 MHz or below) into a selected site within the subject wherein the selected site has been exposed to a stress capable of causing cellular death at the selected site. At least a portion of ultrasound backscattered from the ultrasound transmitted into the selected site is received. The received backscattered ultrasound is compared to a control backscatter measurement. An increase or a decrease in intensity or spectral slope of the received backscattered ultrasound when compared to the control backscatter measurement indicates cellular death or damage at the selected site within the subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.