Methods of making microtablets for drug delivery
US8192659B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 2012 |
| Grant date | Jun 5, 2012 |
| Priority date | — |
| Expiry date | Feb 3, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2095
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.