Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient
US8192740B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 27, 2008 |
| Grant date | Jun 5, 2012 |
| Priority date | — |
| Expiry date | Feb 27, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/77
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An object of the present invention is to provide novel pharmaceutical compositions using anti-GRP78 antibodies. More particularly, the present invention provides a novel method of cancer treatment using anti-GRP78 antibodies, novel cell growth inhibitors and anticancer agents that contain anti-GRP78 antibodies, as well as novel anti-GRP78 antibodies. The present inventor prepared antitumor antibodies to target GRP78, the localization of which in cancer cells changed to the cell membrane. The inventor successfully obtained an anti-GRP78 antibody that would bind specifically to the cell surface of cancer cells, leading to the accomplishment of the above-mentioned objects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.