Pharmaceutical composition for controlled release of a beta-lactam antibiotic
US8192755B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 19, 2001 |
| Grant date | Jun 5, 2012 |
| Priority date | — |
| Expiry date | Mar 23, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved stable pharmaceutical composition for controlled release of an active ingredient comprises a betalactam antibiotic such as cephalexin, cefaclor or their pharmaceutically acceptable hydrates, salts or esters as active ingredient, a calcium salt and a mixture of hydrophilic polymers selected from the group consisting of at least one sodium alginate and one xanthan gum and with or without hydroxypropyl methylcellulose, said composition optionally containing probenecid. The composition may also contain one or more of a water soluble and/or water dispersible diluent, wherein the quantities of the hydrophilic polymers and water soluble and/or water dispersible diluents are such that the therapeutically effective active ingredient is released at a rate suitable for once or twice daily administration of the pharmaceutical composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.