Compositions, methods and devices for preparing less painful Botulinum toxin formulations
US8192979B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2005 |
| Grant date | Jun 5, 2012 |
| Priority date | — |
| Expiry date | Jan 30, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M5/422
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Devices, methods and kits are disclosed for preparing and administering less-painful formulations of Botulinum toxin. The devices, methods and kits of the present invention are comprised of or use an acidic formulation of Botulinum toxin, or, in certain embodiments, a freeze- or flash-dried composition of Botulinum toxin, having a long shelf-life which is subsequently mixed with an acid-neutralizing solution and, optionally a sequestration agent prior to administration to a patient in need thereof. The pH-neutralized formulation of Botulinum toxin is pharmaceutically acceptable for administration to a patient and is significantly less painful than acidic formulations of Botulinum toxin or formulations of Botulinum toxin having unnecessary antigens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.