Heterocyclic FXR binding compounds

US8193192B2 · kind B2 · utility

Assignee

• PHENEX PHARMACEUTICALS AG · DE

Inventors

• Claus Kremoser · Heidelberg, DE
• Ulrich Deuschle · Bammental, DE
• Ulrich Abel · Schifferstadt, DE
• Andreas Schulz · Karben, DE

Key dates

• Filing date: Aug 29, 2007
• Grant date: Jun 5, 2012
• Expiry date: Jan 22, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.