Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1- (4-chloro-2-(3-methyl-1H-pyrazol-1-YL)phenyl)2,2,2-trifluoroethoxy)-pyrimidin-4-YL)phenyl)propanoate and methods of their use

US8193204B2 · kind B2 · utility

Assignee

• LEXICON PHARMACEUTICALS, INC. · US

Inventors

• Mark S. Bednarz · Yardley, US
• Susan Margaret De Paul · Zürich, CH
• Ramanaiah C. Kanamarlapudi · Bound Brook, US
• Anett Perlberg · Gunzgen, CH
• Haiming Zhang · Pennington, US

Key dates

• Filing date: Sep 25, 2008
• Grant date: Jun 5, 2012
• Expiry date: Feb 27, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate and salts thereof are disclosed.