Alpha helical mimics, their uses and methods for their production

US8193310B2 · kind B2 · utility

Assignee

• The University Of Queensland · AU

Inventors

• David Fairlie · Faulconbridge, AU
• Nicholas E. Shepherd · Cardiff, GB

Key dates

• Filing date: Mar 21, 2005
• Grant date: Jun 5, 2012
• Expiry date: May 15, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are short chain peptides that are constrained to adopt an alpha helical conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides. Also disclosed is the use of these peptides for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. The peptides find use in mimicking naturally occurring peptides or proteins or in preparing new materials.