Composite scaffolds and methods using same for generating complex tissue grafts

US8197553B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Dan Gazit · Modiin-Maccabim-Reut, IL
• Abraham J. Domb · Beer Sheva, IL
• Gadi Turgeman · Jerusalem, IL
• Gadi Pelled · Los Angeles, US
• Tony Azzam · Nazareth, IL

Key dates

• Filing date: Sep 29, 2008
• Grant date: Jun 12, 2012
• Expiry date: Dec 4, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/72
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.