EML4-ALK fusion gene
US8197818B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 13, 2011 |
| Grant date | Jun 12, 2012 |
| Priority date | — |
| Expiry date | Apr 13, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.