Mechanism to signal receptor-ligand interactions with luminescent quantum dots

US8198099B2 · kind B2 · utility

Assignee

• The University of Miami · US

Inventors

• Francisco M. Raymo · Kendall, US
• Massimilliano Tomasulo · Miami, US
• Ibrahim Yildiz · Miami, US

Key dates

• Filing date: Jul 9, 2007
• Grant date: Jun 12, 2012
• Expiry date: Oct 21, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/805
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Semiconductor quantum dots are becoming valuable analytical tools for use in biomedical applications. Indeed, their unique properties offer the opportunity to design luminescent probes for imaging and sensing with unprecedented performance. In this context, we have identified operating principles to transduce supramolecular association of complementary receptor-ligand binding pairs into enhancement or suppression in the luminescence of sensitive quantum dots. Thus, complementary receptor-ligand binding pairs can be identified with luminescence measurements relying on our design logic. In fact, we have demonstrated with a representative example that our protocol can be adapted to signal receptor-ligand binding.