Bifunctional polyazamacrocyclic chelating agents
US8198101B2 · kind B2 · utility
1Cited by
4References
12Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 6, 2007 |
| Grant date | Jun 12, 2012 |
| Priority date | — |
| Expiry date | Mar 23, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111Li or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.