Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
US8198231B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Jun 2, 2006 |
| Grant date | Jun 12, 2012 |
| Priority date | — |
| Expiry date | Sep 4, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/24075
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include β-lactams and glycopeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.