Thiophenediamine derivative having urea structure

US8198271B2 · kind B2 · utility

Assignee

• SANTEN PHARMACEUTICAL CO., LTD. · JP

Inventors

• Hiroyuki Mogi · Ikoma, JP
• Hisashi Tajima · Ikoma, JP
• Noriko Mishina · Ikoma, JP
• Yusuke Yamazaki · Ikoma, JP
• Shinji Yoneda · Ikoma, JP
• Katsuhiko Watanabe · Ikoma, JP
• Junko Fujikawa · Ikoma, JP
• Minoru Yamamoto · Ikoma, JP

Key dates

• Filing date: May 25, 2009
• Grant date: Jun 12, 2012
• Expiry date: Jun 13, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound having the following formula (1) or a salt thereof:wherein R1 and R2 represent hydrogen, a lower alkyl, a lower alkenyl, a lower alkynyl or a group having the following formula (2):(R6)n—{circle around (A)}—Z—  (2),R3 represents hydroxy, a lower alkoxy, a lower cycloalkyloxy, an aryloxy, carboxy, a lower alkoxycarbonyl, or —NRaRb having the following formula (3):(R7)o—{circle around (B)}—  (3),R4 and R5 represent halogen, a lower alkyl, hydroxy, or a lower alkoxy; R6 represents halogen, a lower alkyl, an aryl group, a heterocyclic, a hydroxy, a lower alkoxy, mercapto, a lower alkylthio, a lower alkylcarbonyl, amino, nitro or cyano; R7 represents a lower alkyl, hydroxy or a lower alkoxy; Ra and Rb represent hydrogen or a lower alkyl; the ring A represents a cyclic hydrocarbon or a heterocyclic ring; the ring B represents a heterocyclic ring having one or more heteroatoms selected from the group consisting of nitrogen and oxygen; X represents a lower alkylene; Y represents a lower alkylene; Z represents a single bond or a lower alkylene; W1-W2 represents N—CH or C—N and l, m, n and o represent 0, 1, 2, or 3.