Curcumin analogues and uses thereof

US8198323B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• The University of Rochester Medical Center · US
• AndroScience Corporation · US

Inventors

• Kuo-Hsiung Lee · Chapel Hill, US
• Li Lin · New Taipei, TW
• Charles C-Y Shih · Solana Beach, US
• Ching-Yuan Su · Del Mar, US
• Junko Ishida · Tokyo, JP
• Hironori Ohtsu · Matsubara, JP
• Hui-Kang Wang · Carrboro, US
• Hideji Itokawa · Chapel Hill, US
• Chawnshang Chang · Pittsford, US

Key dates

• Filing date: Apr 12, 2010
• Grant date: Jun 12, 2012
• Expiry date: May 21, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C205/45
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.