Stabilized alpha helical peptides and uses thereof

US8198405B2 · kind B2 · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• President and Fellows of Harvard College · US

Inventors

• Loren D. Walensky · Newton, US
• Stanley J. Korsmeyer · Chesterfield, US
• Gregory L. Verdine · Boston, US

Key dates

• Filing date: Jul 30, 2008
• Grant date: Jun 12, 2012
• Expiry date: Jul 30, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.