Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen

US8198416B2 · kind B2 · utility

Assignee

• UNIVERSITAETSKLINIKUM FREIBURG · DE

Inventors

• Ursula Elsässer-Beile · Denzlingen, DE
• Philipp Wolf · Gundelfingen, DE
• Dorothee Gierschner · Teningen, DE
• Patrick Bühler · Glückstadt, DE
• Ulrich Wetterauer · Glückstadt, DE

Key dates

• Filing date: Mar 2, 2006
• Grant date: Jun 12, 2012
• Expiry date: Mar 2, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated monoclonal antibodies or an antigen binding portion thereof which bind to prostate specific membrane antigen in its native form occurring on the surface of tumor cells characterized in that it is linked to a label or a cytotoxic agent or constructed as a part of a bispecific antibody or a recombinant diabody.