Dihydropyridine derivatives as useful as protein kinase inhibitors

US8198456B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Marc Adler · Orinda, US
• Stefan Baeurle · Berlin, DE
• Judi Bryant · Mill Valley, US
• Ming-Syuan Chen · Changsha, CN
• Yuo-Ling Chou · Lafayette, US
• Paul Hrvatin · South San Francisco, US
• Seock-Kyu Khim · Hercules, US
• Monica J. Kochanny · San Rafael, US
• Wheeseong Lee · Orinda, US
• Michael Mamounas · Oakland, US
• Janet Meurer Ogden · Fairfield, US
• Gary Phillips · Issaquah, US
• Victor Selchau · Concord, US
• Christopher William West · El Sobrante, US
• Bin Ye · Moraga, US
• Shendong Yuan · San Ramon, US
• Martin Krueger · Berlin, DE

Key dates

• Filing date: Dec 13, 2007
• Grant date: Jun 12, 2012
• Expiry date: Feb 26, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides novel dihydropyridine derivatives of the formula Ihaving protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.