Reducing the risk of human anti-human antibodies through V gene manipulation
US8198508B2 · kind B2 · utility
1Cited by
30References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 12, 2009 |
| Grant date | Jun 12, 2012 |
| Priority date | — |
| Expiry date | Jan 3, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/56
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included. Methods for determining if various conditions for administering an antibody to a subject enhance or suppress a HAHA response are also included. Some embodiments herein are directed to transgenic mouse embodiments relevant for HAHA responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.