Method for controlled production of ultrafine microparticles and nanoparticles

US8202540B1 · kind B1 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Rainer Muller · Penzberg, DE
• Karsten Krause · Berlin, DE
• Karsten Mader · Berlin, DE

Key dates

• Filing date: Jul 10, 2000
• Grant date: Jun 19, 2012
• Expiry date: Aug 4, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2301/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to superfine microparticles and nanoparticles and a process for their gentle preparation with exclusion of water or minimization of water and/or exclusion of plasticizers and/or reduced temperature load, in which a matrix material is subjected to a high-pressure homogenization process in an anhydrous or water-poor medium and/or at low temperatures, preferably room temperature (20° C.) and in particular below the freezing point of water, which leads to a gentle particle reduction with minimization of the impairment of the chemical stability of the homogenized material.