5-cyanothienopyridines for the treatment of tumours

US8202882B2 · kind B2 · utility

Assignee

• MERCK PATENT GESELLSCHAFT MIT BESHRANK TER HAFTUNG · DE

Inventors

• Guenter Hoelzemann · Seeheim-Jugenheim, DE
• Ulrich Graedler · Weinheim, DE
• Hartmut Greiner · Darmstadt, DE
• Christiane Amendt · Mühltal, DE
• Djordje Musil · Seeheim-Jugenheim, DE
• Per Hillertz · Gothenburg, SE

Key dates

• Filing date: Sep 19, 2008
• Grant date: Jun 19, 2012
• Expiry date: Sep 19, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel 5-cyanothienopyridines of the formula (I), in which R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of TGF-beta receptor kinase, and can be employed, inter alia, for the treatment of tumors.