2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors

US8202887B2 · kind B2 · utility

Assignee

• Janssen R & D Ireland · IE

Inventors

• Herman Augustinus De Kock · Arendonk, BE
• Tim Hugo Maria Jonckers · Heist-op-den-Berg, BE
• Paul Jozef Gabriel Maria Boonants · Mechelen, BE
• Stefaan Julien Last · Lint, BE
• Inge Dierynck · Berchem, BE
• Judith Baumeister · Wuppertal, DE
• Gerben Albert Van 'T Klooster · Breda, NL

Key dates

• Filing date: Jun 22, 2007
• Grant date: Jun 19, 2012
• Expiry date: May 11, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.