Bivalent SMAC mimetics and the uses thereof

US8202902B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Haiying Sun · Ann Arbor, US
• Dongguang Qin · Auburn Hills, US
• Zaneta Nikolovska-Coleska · Ann Arbor, US
• Jianfeng Lu · Ann Arbor, US
• Su Qiu · Ann Arbor, US
• Yuefeng Peng · Ann Arbor, US
• Qian Cai · Ann Arbor, US

Key dates

• Filing date: Nov 13, 2008
• Grant date: Jun 19, 2012
• Expiry date: Nov 18, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.