Compounds for inflammation and immune-related uses

US8202999B2 · kind B2 · utility

Assignee

• Synta Pharmaceuticals Corp. · US

Inventors

• Lijun Sun · Harvard, US
• Shoujun Chen · Bedford, US
• Zhi-Qiang Xia · Acton, US
• Jun Jiang · Shanghai, CN
• Yu Xie · Natick, US
• Junyi Zhang · Lowell, US

Key dates

• Filing date: Jan 6, 2006
• Grant date: Jun 19, 2012
• Expiry date: Jul 12, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of structural formulas (I), (VII) and (XI):or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, X3, Y, Z, L, R1, R2, R3, R18 and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.