Process for production of ionically crosslinked polysaccharide microspheres

US8206622B2 · kind B2 · utility

Assignee

• EYESENSE GMBH · CH

Inventors

• Stefan Kammermeier · Puchheim, DE
• Till Merkel · Neu-Ulm, DE
• Katharina Schmid · Aschaffenburg, DE
• Achim Müller · Aschaffenburg, DE

Key dates

• Filing date: Feb 22, 2005
• Grant date: Jun 26, 2012
• Expiry date: Apr 25, 2027

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J13/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.