Herbal composition for inflammatory disorders

US8206756B2 · kind B2 · utility

Assignee

• Piramal Life Sciences Limited · IN

Inventors

• Vijay Singh Chauhan · Mumbai, IN
• Ashish Suthar · Jamkhed, IN
• Dhananjay Sapre · Mumbai, IN
• Swati Bal-Tembe · Mumbai, IN
• Ashok Kumar Gangopadhyay · Mumbai, IN
• Asha Kulkarni-Almeida · Mumbai, IN
• Sapna Parikh · Mumbai, IN
• Ravindra Dattatraya Gupte · Jamkhed, IN
• Nilesh Madhukar Dagia · Mumbai, IN
• Somesh Sharma · Los Altos, US
• Shruta Sudheer Dadarkar · Mumbai, IN
• Mahesh Gundaji Jadhav · Mumbai, IN
• Aditi Amol Tannu · Mumbai, IN

Key dates

• Filing date: Jul 9, 2009
• Grant date: Jun 26, 2012
• Expiry date: Dec 29, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-α) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1), vascular-cell adhesion molecule 1 (VCAM-1), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory age…