Method for producing red blood cells
US8206979B2 · kind B2 · utility
9Cited by
3References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 11, 2005 |
| Grant date | Jun 26, 2012 |
| Priority date | — |
| Expiry date | Aug 28, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/1394
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythmid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.