Method of generating a dosing schedule using gamma secretase notch biomarkers
US8206989B2 · kind B2 · utility
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Key dates
| Filing date | Jun 22, 2011 |
| Grant date | Jun 26, 2012 |
| Priority date | — |
| Expiry date | Jun 22, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/575
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical testing. The reagents and methods of the invention can be used to identify and maintain preferred doses of test compounds and thereby prevent medical complications, such as gastrointestinal cellular damage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.