Methods of inhibiting viral infection
US8207209B2 · kind B2 · utility
0Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 23, 2008 |
| Grant date | Jun 26, 2012 |
| Priority date | — |
| Expiry date | Dec 31, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting viral respiratory infection in a mammal in need of same, includes administering an effective amount of 2-[2-(5-carbamimidoyl-benzofuran-2-yl)-vinyl]-H-benzoimidazole-5-carboxamidine or the Bis-N-hydroxyamidine prodrug thereof, prior to viral infection, or therapeutically following viral infection, to inhibit that viral infection. The compound selectively inhibits Caspase 2 and/or 8 as to prevent infective viral particle release. It is optionally administered IV, IP, orally or via other conventional administration routes in a dosage range of 1 ng/kg-200 mg/kg of body weight.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.