Methods of separating biopolymer conjugated molecules from unconjugated molecules
US8207298B2 · kind B2 · utility
2Cited by
6References
55Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 1, 2009 |
| Grant date | Jun 26, 2012 |
| Priority date | — |
| Expiry date | May 19, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/36
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.