Method of obtaining idolocarbazoles using biosynthetic rebeccamycin genes
US8207321B2 · kind B2 · utility
0Cited by
0References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 2002 |
| Grant date | Jun 26, 2012 |
| Priority date | — |
| Expiry date | Dec 24, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.