Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA

US8211401B2 · kind B2 · utility

Assignee

• Molecular Insight Pharmaceuticals, Inc. · US

Inventors

• John W. Babich · Cambridge, US
• Craig Zimmerman · Topsfield, US
• John Joyal · Melrose, US
• Kevin P. Maresca · Tewksbury, US
• Genliang Lu · Winchester, US
• Shawn Hillier · Danvers, US

Key dates

• Filing date: Dec 4, 2009
• Grant date: Jul 3, 2012
• Expiry date: Dec 31, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F13/005
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof:complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.