Mutant having uracil phosphoribosyl transferase activity
US8211421B2 · kind B2 · utility
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3References
7Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 30, 2009 |
| Grant date | Jul 3, 2012 |
| Priority date | — |
| Expiry date | Aug 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.