TNFα-neutralizing antibodies

US8211433B2 · kind B2 · utility

Assignee

• EPITOMICS, INC. · US

Inventors

• Fernando Jose Rebelo Do Couto · Pleasanton, US
• Kristin Beth Hendricks · Redwood City, US
• Stacey Ellen Wallace · Sunnyvale, US

Key dates

• Filing date: Apr 29, 2011
• Grant date: Jul 3, 2012
• Expiry date: Apr 29, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from those rabbit monoclonal antibodies. In certain embodiments, the monoclonal antibodies may be humanized. Methods of using the subject antibodies to inhibit TNFα activity, methods of treatment using those antibodies and kits containing the same are also provided. The invention finds use in a variety of research and medical applications.