Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
US8211443B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 4, 2006 |
| Grant date | Jul 3, 2012 |
| Priority date | — |
| Expiry date | Oct 12, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.