Identification of a family of secreted proteins in vascular endothelium
US8211640B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Dec 18, 2008 |
| Grant date | Jul 3, 2012 |
| Priority date | — |
| Expiry date | Dec 18, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/485
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.